Investigating the Impact of Kratom (Mitragyna speciosa) Use Upon Male Sexual Health

Abstract

Purpose

Kratom (Mitragyna speciosa) exhibits μ-receptor agonism and is used as an opioid substitute. While opioids are known to inhibit sexual behavior, less is known regarding kratom. We conducted a pilot study to assess the subjective impact of kratom upon male sexual health including erectile and ejaculatory function.

Patients and Methods

Twitter and Reddit (r/Kratom) were accessed to disseminate our survey featuring validated instruments (the International Index of Erectile Function, IIEF, and the premature ejaculation diagnostic tool, PEDT). Sexual health prior to and after 4 weeks of kratom use was assessed.

Results

Most males surveyed (n = 165) were 18–40 years old (84.9%), with 95.8% of respondents using it at least weekly and 82.4% using kratom for ≥1 year. Reasons for use included treating pain (39.4%), and mental health conditions (63.6%). Kratom was associated with a positive (37.7%) and negative (20.5%) impact on sexual health. Kratom subjectively increased time to ejaculation in 104 (66.6%) patients, perceived as positive by 62 (59.6%). Seventy-eight patients answered questions about premature ejaculation. The median (with interquartile range, IQR, following;) pre-kratom and kratom use scores were 13.0; 8.0 and 6.5; 5.0, respectively (p < 0.001). Ejaculation before 5 minutes improved after kratom (51.3% vs 12.8%) (p < 0.0001). Following kratom use, patients reported lack of frustration with ejaculation prior to desire (21.8% vs 61.5%) (p < 0.001). The erectile function domain of the IIEF was statistically significantly different however – clinically similar pre-kratom use (29.0; 5.75) versus 27.0; 6.75 during kratom use (p = 0.037).

Conclusion

Clinicians treating male sexual health should be aware of kratom and its potential effect on ejaculatory and erectile function.

Keywords: kratom, Mitragyna speciosa, premature ejaculation, analgesia, sexual function

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Abstract

Background

Kratom (Mitragynia speciosa korth) is recognized increasingly as a remedy for opioid withdrawal by individuals who self-treat chronic pain.

Case description

A patient who had abruptly ceased injection hydromorphone abuse self-managed opioid withdrawal and chronic pain using kratom. After co-administering the herb with modafinil he experienced a tonic-clonic seizure, but he reported only modest abstinence once kratom administration stopped. We confirmed the identity of the plant matter he ingested as kratom and identified no contaminants or adulterants. We also conducted high-throughput molecular screening and the binding affinity at mu, delta and kappa receptors of mitragynine.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3670991/

Kratom for opioid withdrawal: Does it work?

Kratom, an herbal extract from the leaves of an evergreen tree (Mitragyna speciosa) that grows in Southeast Asia, is promoted as a treatment for withdrawal. While kratom is sold as a dietary supplement in some states in the U.S., it is not approved by the Food and Drug Administration (FDA) for any medical use. The FDA warns people not to use it due to the risk of addiction, misuse and dependence. Kratom is illegal in some states and some countries.

https://www.mayoclinic.org/diseases-conditions/prescription-drug-abuse/in-depth/kratom-opioid-withdrawal/art-20402170

In Asia, people have used kratom in small amounts to reduce tiredness or treat opium addiction. In other parts of the world, people take kratom to try to ease opioid withdrawal, feel more energetic, relieve pain, or reduce anxiety or depression. People take kratom to ease withdrawal because it may make them feel happy and they can get kratom more easily than drugs prescribed for withdrawal.

ScienceDirect.com https://www.sciencedirect.com › article › abs › pii

by D Singh · 2020 · Cited by 13 — Of those who reported not using kratom to enhance sexual performance, 7/20 (35%) also experienced improved sexual performance after kratom use.

Investigating the Impact of Kratom (Mitragyna speciosa) ...

National Institutes of Health (NIH) (.gov)

https://pmc.ncbi.nlm.nih.gov › articles › PMC9926986

by NA Deebel · 2023 · Cited by 4 — Kratom use reportedly increased time to ejaculation in 104 (66.6%) patients, which was perceived as a positive effect by 62 (59.6%).

Improved sexual functioning of long-term daily users ...

ScienceDirect.com

https://www.sciencedirect.com › article › abs › pii

by D Singh · 2020 · Cited by 13 — Of those who reported not using kratom to enhance sexual performance, 7/20 (35%) also experienced improved sexual performance after kratom use.

Does kratom make you happy?

When the level of these neurotransmitters is increased in the brain, it makes a person feel good, thereby elevating mood. Opioid abuse causes a high that leaves a person feeling euphoric, mellow, and less sensitive to pain. Kratom abuse may have similar effects. In some cases, kratom exposure has resulted in psychosis.Jul 19, 2024

Does kratom make you horny?

24 Finally, a survey-based study examining long-term, kratom users in Penang, Malaysia, showed increased energy during sex, delay in time to ejaculation, increased sexual desire, and increased ability to maintain an erection.Feb 10, 2023

https://pmc.ncbi.nlm.nih.gov/articles/PMC9926986/

Health Benefits of Kratom

https://www.webmd.com/diet/health-benefits-kratom

Kratom could potentially be used for the treatment of opioid withdrawal and pain, but more insight is needed into its abuse potential.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7542979/

Does kratom affect sexual function? The ability to obtain/maintain an erection was subjectively impaired in 23.1% (n=36) while improved in 23.7% (n=37) of the participants (p > 0.05). Kratom use reportedly increased time to ejaculation in 104 (66.6%) patients, which was perceived as a positive effect by 62 (59.6%).Feb 10, 2023

https://www.dovepress.com/investigating-the-impact-of-kratom-mitragyna-speciosa-use-upon-male-se-peer-reviewed-fulltext-article-RRU

https://academic.oup.com/jsm/article/20/Supplement_1/qdad060.178/7164699

https://www.mayoclinic.org/diseases-conditions/prescription-drug-abuse/in-depth/kratom/art-20402171

https://www.sciencedirect.com/science/article/abs/pii/S2210803319300405

https://pubmed.ncbi.nlm.nih.gov/36798621/

https://www.euda.europa.eu/publications/drug-profiles/kratom_en

What are the healthy benefits of kratom?

Possible Health Benefits of Kratom

So it's uncertain if kratom may be effective when taken to treat certain conditions. People in Asia, where kratom is grown, have used kratom for over a century. They believe that it prevents diarrhea, decreases pain, aids opioid withdrawal and enhances libido.Jun 23, 2023

What is mitragynine pain relief?

Kratom (Mitragyna speciosa) is a tree native to Southeast Asia. The leaves contain a chemical called mitragynine, which works like opioids such as morphine. Kratom has pain-relieving effects like opioid drugs. It also has many of the same serious safety concerns as other opioids

https://pubmed.ncbi.nlm.nih.gov/36503042/

https://www.webmd.com/vitamins/ai/ingredientmono-1513/kratom

https://www.sciencedirect.com/science/article/abs/pii/S1526590024007041

https://www.sciencedirect.com/science/article/pii/S0753332224000155

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